Come and play the one piece mmorpg! Envision a state of affairs in which it turns out there was an actual oversight with the movements and you need to return again to a past model. New to the Bioinformatics Hyperlinks Directory in 2009 is the addition of Gene Set Analysis, a new subcategory beneath instruments for Expression analysis (Table 1), addressing the necessity and introduction of recent assets that facilitate data integration and useful evaluation of gene sets recognized through expression or genome extensive affiliation research. Reflecting again on the historical past of the NAR Net Server problem and the Bioinformatics Links Directory, and on informatics over the previous few years, it is interesting to note how analysis and the sector of bioinformatics have modified in such a brief timeframe. In many situations there are sharp spikes in the number of informatics tools accessible in a given biological space or particular to a particular task. Indeed in 2008, a brand new subcategory for Network evaluation was added to accommodate informatics instruments and resources that take a methods approach to biological problems. Prominent in research in the present day has been the introduction and software of assorted subsequent-generation sequencing platforms to a wide range of research problems from rapid de novo sequencing (7), to genomic analysis of polymorphisms and different mutation events (8), and analyses of the transcriptome of various RNA macromolecules (9) and the epigenome (10). Given the amount and variety of data being produced by these new high-throughput applied sciences, there may be an increased need for instruments in meta-data analysis, data integration and information mining that facilitate data exploration and supply opportunities for novel discoveries without the concomitant requirement for personal computational capacity.